Up All Night Season 2 Set Visit | Pictures

Up All Night's second season promises some life-altering changes for the Brinkleys, and this week, we swung by the set during the taping of the show's upcoming premiere episode. Warning: a few spoilers lie ahead! The season kicks off with the unceremonious cancellation of Ava's talk show, putting both Ava (Maya Rudolph) and Reagan (Christina Applegate) out of a job. Meanwhile, fans can expect a new face on the sitcom: Reagan's brother, Scott (Luka Jones). With Reagan and Chris (Will Arnett) trading roles as the stay-at-home parent and the breadwinner, Chris decides to start a business venture with his brother-in-law.

Click through to hear more from the show's cast and producers on what's ahead this year and to see Maya and Christina in action filming a scene from the premiere episode. Up All Night returns to NBC on Sept. 20.