Smart is one of my favorite parts of Samantha Who? She and Christina Applegate play off each other so well, and the episode Smart submitted ("The Girlfriend") was a good one for showing off her character's mean, snarky side. That said, if the voters are going for mean-funny this year, I'm not sure she's the best choice in the category.
Chance of winning: Moderate
Photo copyright 2008 ABC, Inc