Samantha Who? was one of last season's few breakout hits, and I give most of the credit for that to Applegate. She made a fabulous return to TV, and I loved watching her play both the new, good, amnesiac Samantha and the old, bad-girl version of her character. She carried most of the show's weight with her sparkling performance, and I wouldn't be shocked to see her rewarded.
Chance of winning: High
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