Hugh Laurie and Jon Hamm are probably the most popular contenders (when it comes to average viewers, anyway) in this category, and they're both so deserving of the gold. Both are responsible for making these intelligent, flawed and often prickly characters sympathetic, and I think they both accomplish this with a tremendous delicacy. This is Laurie's fourth nomination in a row, though, and I have a nagging suspicion that he might finally actually win. Or maybe that's my nagging hope. He so deserves this award.
Chances of winning: High.
Photo courtesy of Fox