Opening to the tune of over $45 million in box office sales this weekend, Dr. Seuss' Horton Hears A Who has nabbed the best opening weekend so far in 2008. The title previously belonged to the January release of Cloverfield which raked in $41 million. Twentieth Century Fox's senior VP of distribution Chris Aronson quipped about Horton's success, "It's a who-mongous opening."

In second place, pulling in way less than Horton's giant pile o' cash was last weekend's holdover, 10,000 B.C. with $16.4 million, followed by Never Back Down, a martial arts drama that took in $8.6 million. College Road Trip was No. 4, with oldie-but-goody Vantage Point rounding out the top five. New release Doomsday did poorer than was expected, coming in at No. 7 with $4.7 million.

This weekend it'll be interesting to see if any of the newbies will be able to knock off Horton's crown: Drillbit Taylor starring Owen Wilson, Tyler Perry's Meet the Browns and the Joshua Jackson thriller Shutter will be the only real competitors.

Image courtesy of 20th Century Fox